2012 Fiscal Year Final Research Report
The analysis of the mechanisms by which volatile anesthetics and propofol induce apoptosis of immune cells.
| Project/Area Number |
22591702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 麻酔学 |
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| Research Abstract |
In this study, volatile anesthetics induced thymocyte apoptosis and reduced mitochindrial membrane potential in thymocytes dose- and time-dependently. In addition, the reduction of mitochondrial membrane potential preceded the induction of thymocyte apoptosis. Probably, reduction of mitochondrial membrane potential in thymocytes is one of the initial events.
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