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2012 Fiscal Year Final Research Report

The analysis of molecular mechanism of immuno-suppressive activity of midazolam on dendritic cell

Research Project

  • PDF
Project/Area Number 22591708
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

GOTO Yukiko  大阪大学, 大学院・医学系研究科, 助教 (20276710)

Co-Investigator(Kenkyū-buntansha) FUJINO Yuji  大阪大学, 大学院・医学系研究科, 教授 (50252672)
OHTA Noriyuki  大阪大学, 医学部附属病院集中治療部, 助教 (60379162)
Project Period (FY) 2010 – 2012
Keywords樹状細胞 / リンパ球 / インターロイキン 12 / インターフェロンγ / 副刺激分子 / 接触過敏症
Research Abstract

Midazolam is a widely-used sedative drug in critical care and anesthesia. We analyzed the effect of midazolam on the function of dendritic cells. Midazolam suppressed the functional maturation of dendritic cells by lipopolysaccharidein terms of the expression of costimulatory molecules and IL-12. Midazolam-treated dendritic cells inhibited the allostimulatory activity of dendritic cells. Midazolam-treated dendritic cells have reduced activity inducing contact hypersensitivity response, one of typical cell-mediated immune responses. It was suggested that these inhibitory effects of midazolam is mediated by the effect on peripheral benzodiazepine receptor (PBR) by the study using PBR-specific ligand.

  • Research Products

    (6 results)

All 2013 2012 2011 2010

All Presentation (6 results)

  • [Presentation] ミダゾラムは自己非自己の認識能を低下させる2013

    • Author(s)
      大田典之
    • Organizer
      第60回日本麻酔科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-23
  • [Presentation] ミダゾラムは樹状細胞による抗原特異的な免疫応答を抑制する2013

    • Author(s)
      大田典之
    • Organizer
      第40回日本集中治療医学会総会
    • Place of Presentation
      松本
    • Year and Date
      2013-03-02
  • [Presentation] プロポフォールは樹状細胞によって誘導される Th1 型免疫応答を促進する2012

    • Author(s)
      大田典之
    • Organizer
      第59回日本麻酔科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-06-08
  • [Presentation] 敗血症は粘膜免疫応答を低下させる2012

    • Author(s)
      大田典之
    • Organizer
      第39回日本集中治療医学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-01
  • [Presentation] 樹状細胞の機能に対する鎮静薬の機能の多様性2011

    • Author(s)
      大田典之
    • Organizer
      第38回日本集中治療医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
  • [Presentation] ミダゾラムは樹状細胞によって惹起されるTh1 型の免疫応答を抑制する2010

    • Author(s)
      大田典之
    • Organizer
      第57回日本麻酔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03

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Published: 2014-08-29   Modified: 2018-02-02  

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