2012 Fiscal Year Final Research Report

The analysis of molecular mechanism of immuno-suppressive activity of midazolam on dendritic cell

Research Project

Project/Area Number	22591708
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Osaka University
Principal Investigator	GOTO Yukiko 大阪大学, 大学院・医学系研究科, 助教 (20276710)
Co-Investigator(Kenkyū-buntansha)	FUJINO Yuji 大阪大学, 大学院・医学系研究科, 教授 (50252672) OHTA Noriyuki 大阪大学, 医学部附属病院集中治療部, 助教 (60379162)
Project Period (FY)	2010 – 2012
Keywords	樹状細胞 / リンパ球 / インターロイキン 12 / インターフェロンγ / 副刺激分子 / 接触過敏症
Research Abstract	Midazolam is a widely-used sedative drug in critical care and anesthesia. We analyzed the effect of midazolam on the function of dendritic cells. Midazolam suppressed the functional maturation of dendritic cells by lipopolysaccharidein terms of the expression of costimulatory molecules and IL-12. Midazolam-treated dendritic cells inhibited the allostimulatory activity of dendritic cells. Midazolam-treated dendritic cells have reduced activity inducing contact hypersensitivity response, one of typical cell-mediated immune responses. It was suggested that these inhibitory effects of midazolam is mediated by the effect on peripheral benzodiazepine receptor (PBR) by the study using PBR-specific ligand.

(6 results)