2013 Fiscal Year Final Research Report
Evaluation of neuroprotective efficacy by the regulation of microglial activation in models of spinal cord ischemia
| Project/Area Number |
22591715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 脊髄虚血 / ミクログリア / ミノサイクリン |
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| Research Abstract |
Although minocycline has been shown to have neuroprotective effects in models of cerebral ischemia, there have been no data available regarding the effects of minocycline in a model of spinal cord ischemia (SCI). In the first study, we investigated the effects of minocycline in a rat model of SCI. Minocycline was intraperitoneally administered for 3 days beginning at 12 hours before 10 minutes of SCI. The results indicated that minocycline administration improved hind-limb motor function and attenuated gray and white matter injury. In the second study, we investigate whether postischemic administration of minocycline attenuates hind-limb motor dysfunction and gray and white matter injuries after SCI in rabbits. The results indicated that minocycline administration beginning at 1 hour after reperfusion improved hind-limb motor dysfunction and attenuated gray matter injury after SCI in rabbits. These results indicated that minocycline can be a candidate for neuroprotection for SCI.
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