2012 Fiscal Year Final Research Report
A new approach to explore the mechanism of anesthesia-induced unconsciousness. - The role of the hypothalamic MCH neurons -
| Project/Area Number |
22591718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Hidetoshi 帝京大学, 医学部, 助教 (90349267)
MORITA Shigeho 帝京大学, 医学部, 教授 (60143476)
SAWAI Jyun 帝京大学, 医学部, 助手 (20527410)
TAKATA Jyunko 帝京大学, 国際教育研究所, 助手 (00527418)
SENTHO Yoshiki 帝京大学, 国際教育研究所, 助手 (80527416)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メラニン凝集ホルモン / 睡眠・覚醒 / 記憶 / 麻酔 |
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| Research Abstract |
We investigated the effects of melanin concentrating hormone (MCH) on sleep-wake cycle. Intraventricular (icv) injection of MCH decreased the waking episode time, whereas it increased the sleep episode time (REM & nonREM episode time). It has been reported that sleep is necessary for consolidation of memory with increasing the hippocampal acetylcholine (ACh). In the present study, icv injection of MCH increased the hippocampal ACh. There was a significant correlation between REM episode time and hippocampal ACh effluxes. Icv injection of MCH did not alter the cortical histamine release. These findings suggest that MCH may contribute to the consolidation of memory. Further experiment is necessary to explore whether the memory function of MCH may be involved in the anesthetic state.
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