2012 Fiscal Year Final Research Report
Involvement of receptor for advanced glycation end products for hyperglycemia-induced aggravation of white matter damage by cerebral ischemia
| Project/Area Number |
22591720
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 全脳虚血 / 高血糖 / 脳白質 / 活性酸素 |
|---|
| Research Abstract |
Global cerebral ischemia was induced by 5 min of cardiac arrest and resuscitation (CAR) in male rats with or without acute glucose administration (2g/kg i.p.). Two weeks after the CAR, the brain was extracted and brain slices were prepared. Microglial activation, neuronal and axonal injuries, and RAGE (receptor for advanced glycation end products) expression were detected in the hippocampal CA1 region in both groups, i.e., a glucose-administered group and a vehicle-administered group, but the statistically significant differences of those were not detected between the two groups. Neurologic deficit scores, which can detect functional damage in the brain, were similar in the both groups. I assume that the reason is due to the fact that sample size was not enough or that CAR alone caused rather hyperglycemia.
|
