2012 Fiscal Year Final Research Report
The analysis and treatment of immuno-suppressive state in cellular immunity induced by sepsis
| Project/Area Number |
22591728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
OHTA Noriyuki 大阪大学, 医学部附属病院, 助教 (60379162)
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| Co-Investigator(Kenkyū-buntansha) |
FUJINO Yuji 大阪大学, 大学院・医学系研究科, 教授 (50252672)
GOTO Yukiko 大阪大学, 大学院・医学系研究科, 助教 (20276710)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 敗血症 / 免疫応答 / 細胞傷害性リンパ球 / 粘膜免疫 / サイトカイン / PD-L1 / コレラ毒素 |
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| Research Abstract |
We analyzed the immunosuppressive state after recovery from sepsis induced by peritonitis in mice. We mainly used experimental system analyzing antigen-specific immune-response induced by mucosal immunization method. In mice recovered from sepsis, antigen-specific immune-response was depressed in terms of cellular immunity. Furthermore, we tried the improvement of depressed immune-response by intervention into PD-1 and PD-L1 signalling.
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