2012 Fiscal Year Final Research Report
Protective effect of phosphoenolpyruvate on acute lung injury
| Project/Area Number |
22591729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 周術期管理学 |
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| Research Abstract |
Phosphoenolpyruvate (PEP) is an endogenous substance that is one of the ATP precursors and can cross some cell membranes via anion exchanger. We investigated the effects of PEP on ischemia/reperfusion (IR)-induced lung injury. Isolated rabbit lungs were divided into the following groups: control (n=6), perfused and ventilated without ischemia; IR (n=6), ischemia for 60min, followed by reperfusion; PEP-IR (n=6), 1mM PEP was administered for 30min before ischemia, followed by IR. The administration of PEP before ischemia significantly attenuated the increases in IR-induced coefficient of filtration and wet to dry ratio, and caused the increase in pyruvate in the perfusate.
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