2012 Fiscal Year Final Research Report
Changes of serum inflammatory mediator levels during early graft failure after lung transplantation and the diagnostic value
| Project/Area Number |
22591731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Okayama University |
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Principal Investigator |
GOTO Keiji 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00234980)
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| Co-Investigator(Kenkyū-buntansha) |
OTO Takahiko 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40452578)
MIZOBUCHI Satosi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70311800)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 周術期管理学 / 肺移植 / グラフト機能不全 / 炎症性メディエーター |
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| Research Abstract |
We performed twenty-eight lung transplantations (brain-dead lung transplant: 20 patients, living-donor lober lung transplant: 8 patients) for 3 years in Okayama University Hospital. All patients survived. Owing to our improvements in surgical technique, anesthesia, and postoperative management, no early graft failure developed. Serum levels of interleukin-6 and polymorphonuclear elastase increased during and after cardiopulmonary bypass, but there was no significant change in serum level of these inflammatory cytokines after lung transplantation.
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