2012 Fiscal Year Final Research Report
Mechanisms of the inhibition effects of propofol on adiponectin secretion and its role of insulin resistance
| Project/Area Number |
22591741
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kagoshima University |
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Principal Investigator |
KANMURA Yuichi 鹿児島大学, 大学院・医歯学総合研究科, 教授 (30211189)
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| Research Collaborator |
MORIYAMA Takahiro 鹿児島大学, 大学院・医歯学総合研究科, 助教 (20593651)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 周術期管理学 / アディポネクチン / プロポフォール / インスリン |
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| Research Abstract |
We investigated the effects and mechanisms of propofol, an intravenous anesthetics, on adiponectin, which is the protein hormone secreted from adipose tissue. Propofol dose-dependently inhibited the secretion of adiponection from cultured adipose cells, and also lowered the concentrations of adiponectin in the rats in vivo. We investigated the mechanisms of this inhibitory effects, and found that propofol directly enhanced the phosphorylation of JNK in adipose cells and inhibited the secretion of adiponectin, not by the activation of GABA receptor, which is the main target of propofol anesthetic action.
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