2012 Fiscal Year Final Research Report

Impact of pain on the learning and memory - Behavioral assessment and histological and physiological study in the central nervous system -

Research Project

Project/Area Number	22591744
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Yokohama City University
Principal Investigator	OGAWA Ken-ichi 横浜市立大学, 附属病院, 准教授 (10233412)
Co-Investigator(Kenkyū-buntansha)	SHINBORI Hironobu 横浜市立大学, 医学部, 講師 (60404993) KAMIYA Yoshinori 横浜市立大学, 医学研究科, 客員講師 (90381491)
Project Period (FY)	2010 – 2012
Keywords	術後疼痛 / 記憶学習 / 海馬
Research Abstract	The aim of this study is to clarify the impact of pain and its analgesia on memory and learning. We investigated the effects of acute postoperative pain on fear stimulus memories, one trial passive avoidance learning test was performed using a rat simple laparotomy model. We performed IA-conditioning to the rats 2 hours after the surgery and we conducted IA-test to 24 hours after surgery. Contrary to the expectations, latency to the entering black box had not changed in both groups. Furthermore, we compared the amount of GluA1 subunit of AMPA receptor, which is known to be involved in learning and memory in the hippocampus, in hippocampus synaptosome 24 hours after surgery and there was no difference between laparotomy group and control group. The results of this study suggested that postoperative acute pain may not directly affect the learning and memory disorders of perioperative period.