2012 Fiscal Year Final Research Report
Study of long-term side effects of morphine intrathecal administration in cancer pain model
| Project/Area Number |
22591750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KONDO Ichiro 東京慈恵会医科大学, 医学部, 准教授 (50266623)
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| Co-Investigator(Kenkyū-buntansha) |
NAGANUMA Keiko 東京慈恵会医科大学, 医学部, 助教 (70277086)
FUJIGASAKI Jyunko 東京慈恵会医科大学, 医学部, 講師 (60312021)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 癌性疼痛 / モルヒネ / 髄腔内投与 |
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| Research Abstract |
Analgesic doses of IT morphine and IT DEX infusion produce tolerance. Co-administration of low doses of IT DEX with IT morphine has significant analgesia without tolerance. Severe impression of the spinal cord along the course of the catheter indicating granuloma formation could be seen in morphine infusion animals. Addition of low dose of IT DEX inhibits IT morphine infusion-induced granuloma formation followed by motor impairment. However, IT DEX and morphine provided a littleanalgesic effects in a rat model of cancer induced bone pain. Development of tolerance and granuloma formation followed by motor impairment induced by chronic IT morphine were inhibited by addition of DEX. Combination of IT morphine and DEX may contribute to patients with chronic cancer pain to avoid side effects.
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