2012 Fiscal Year Final Research Report
Investigations of painmechanism related to ATP receptors aiming at new analgesics for cancer pain
| Project/Area Number |
22591756
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORISHITA Takafumi 産業医科大学, 医学部, 講師 (40369070)
OOKURA Dan 産業医科大学, 医学部, 産業医学修練医 (00596710)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 疹痛管理学 |
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| Research Abstract |
We investigated the effects of several analgesics on many subtypes of ATP receptors, and revealed that local anesthetics, lidocaine inhibited the function of P2×7,0ne of the ATP receptor subtypes. We demonstrated that this effect happen through direct effect of lidocaine on P2×_7 receptor, and is non-competitive inhibition. These results suggest that inhibition of P2×_7 function by lidocaine is one of the mechanisnls of analgesic effects by lidocaine for cancer pain, which are still unknown, and indicate the possibility of development of new analgesics for cancer pain by further research about this mechanism.
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Research Products
(1 results)
