Molecular mechanism of hormone-independent progression of prostatecancer: Its clinical application to personalized medicine

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591761
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Toho University
• Principal Investigator: SUZUKI Hiroyoshi 東邦大学, 医学部, 教授 (60301818)
• Project Period (FY): 2010 – 2012
• Keywords: 前立腺癌 / ホルモン療法 / 去勢抵抗性 / 骨転移 / バイオマーカー

Research Abstract

In order to clarify molecular mechanism of hormone-independent progression of prostate cancer, metastatic and/or castration-resistant prostate cancer cases were analyzed by clinical and/or molecular approaches. From these results, some molecular pathway of this process were investigated and new biomarkers were developed. Especially, we reported that OPG-RANK-RANKL pathway is found to be useful for predicting prognosis and Zoledronic acid, a bone modifying agent, has anti-tumor effect on metastatic prostate cancer cases. Also, wefound anti-tumor effect of dendritic cells induced by Sndai virus vector in rat prostate cancer model.

Research Products

• [Journal Article] Analysis of preoperative detection for apex prostate cancer by transrectal biopsy (2013)
  • Author(s): Sazuka T, Imamoto T, Namekawa T, Utsumi T, Yanagisawa M, Kawamura K, Kamiya N, Suzuki H, Ueda T, Ota S, Nakatani Y, Ichikawa T:
  • Journal Title: Prostate Cancer
  • DOI: DOI: 10.1155/2013/705865
  • Peer Reviewed
• [Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration- resistant prostate cancer: a retrospective multi-institutional collaborative study (2013)
  • Author(s): Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T
  • Journal Title: Int J Clin Oncol
  • DOI: DOI: 0.1007/s10147-012-0510-9 DOI: 10.1371/journal.pone.0042456
  • Peer Reviewed
• [Journal Article] Development of a nomogram for predicting the stone-free rate after transurethral ureterolithotripsy using semi-rigid ureteroscope (2012)
  • Author(s): Imamura Y, Kawamura K, Sazuka T, Sakamoto S, Imamoto T, Nihei N, Suzuki H, Okano T, Nozumi K, Ichikawa T
  • Journal Title: Int J Urol
  • DOI: DOI: 10.1371/journal.pone.0042456
  • Peer Reviewed
• [Journal Article] FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway (2012)
  • Author(s): Imamura Y, Sakamoto S, Endo T, Utsumi T, Fuse M, Suyama T, Kawamura K, Imamoto T, Yano K, Uzawa K, Nihei N, Suzuki H, Mizokami A, Ueda T, Seki N, Tanzawa H, Ichikawa T
  • Journal Title: PLoS One Volume: 7 (8) Pages: e42456
  • Peer Reviewed
• [Journal Article] Active surveillance criteria for prostate cancer: Can they be applied to Japanese patients ? (2012)
  • Author(s): Goto Y, Nozumi K, Miyazaki K, Matsumoto A, Inoue A, Kito H, Hasegawa N, Nagata M, Kakuta Y, Suzuki H, Yamaguchi K
  • Journal Title: Int J Urol Volume: 19 Pages: 163-166
  • DOI: DOI:10.1111/j.1442-2042.2011.02900.x
  • Peer Reviewed
• [Journal Article] Additive effect of zoledronic acid on serum prostate-specific antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade (2012)
  • Author(s): Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Nishimi D, Kawamura K, Imamoto T, Ichikawa
  • Journal Title: Additive effect of zoledronic acid on serum prostate-specific antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade Volume: 19(2) Pages: 169-173
  • DOI: DOI:10.1111/j.1442-2042.2011.02914.x
  • Peer Reviewed
• [Journal Article] Biochemical failure after carbon ion radiotherapy for prostate cancer (2012)
  • Author(s): Shimazaki J, Tsuji H, Ishikawa H, Kamada T, Harada M, Akakura K, Suzuki H, Ichikawa T, Tsujii H
  • Journal Title: Anticancer Res Volume: 32 Pages: 3267-3274
  • URL: http://ar.iiarjournals.org/content/32/8/3267.full.pdf+html
  • Peer Reviewed
• [Journal Article] Carbon ion radiotherapy in advanced hypofractionated regimens for prostate cancer: From 20 to 16 fractions (2012)
  • Author(s): Okada T, Tsuji H, Kamada T, Akakura K, Suzuki H, Shimazaki J, Tsujii H and the working group for genitourinary tumors
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84 (4) Pages: 968-972
  • DOI: DOI: 10.1016/j.ijrobp.2012.01.072
  • Peer Reviewed
• [Journal Article] Clinical usefulness of bone markers in prostate cancer with bone metastasis (2012)
  • Author(s): Kamiya N, Suzuki H, Endo T, Yano M, Naoi M, Nishimi D, Kawamura K, Imamoto T, Ichikawa T
  • Journal Title: Int J Urol Volume: 19(11) Pages: 968-979
  • DOI: DOI: 10.1111/j.1442-2042.2012.03098.x
  • Peer Reviewed
• [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor κB ligand in Japanese prostate cancer patients with bone metastasis (2011)
  • Author(s): Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Kawamura K, Imamoto T, Takanami M, Ichikawa T
  • Journal Title: Int J Clin Oncol Volume: 16(4) Pages: 366-372
  • DOI: DOI: 10.1007/s10147-011-0193-7
  • Peer Reviewed
• [Journal Article] External validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology among Japanese patients (2010)
  • Author(s): Imamoto T, Suzuki H, Utsumi T, Takano M, Suyama T, Kawamura K, Kamiya N, Naya Y, Ueda T, Ichikawa T
  • Journal Title: Urology Volume: 76 Pages: 404-410404-410
  • DOI: DOI: 10.1016/j.urology.2009.05.084
  • Peer Reviewed
• [Journal Article] Implications of body mass index in Japanese patients with prostate cancer who had undergo radical prostatectomy (2010)
  • Author(s): Komaru A, Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Kawamura K, Imamoto T, Ichikawa T
  • Journal Title: Jpn J Clin Oncol Volume: 40 Pages: 353-359
  • DOI: DOI: 10.1093/jjco/hyp164
  • Peer Reviewed
• [Journal Article] Komiya A, Shimbo M, Suzuki H, Imamoto T, Kato T, Fukasawa S, Kamiya N, Naya Y, Mori I, Ichikawa T (2010)
  • Author(s): Komiya A, Shimbo M, Suzuki H, Imamoto T, Kato T, Fukasawa S, Kamiya N, Naya Y, Mori I, Ichikawa T
  • Journal Title: Oncology Letters 1 Volume: 1 Pages: 73-79
  • DOI: DOI: 10.3892/ol_00000013
  • Peer Reviewed
• [Journal Article] Implications of serum bone turnover markers in prostate cancer patients with bone metastasis (2010)
  • Author(s): Kamiya N, Suzuki H, Yano M, Endo T, Takano M, Komaru A, Kawamura K, Sekita N, Imamoto T, Ichikawa T
  • Journal Title: Urology Volume: 75 Pages: 1446-1451
  • DOI: DOI: 10.1016/j.urology.2009.11.049
  • Peer Reviewed
• [Journal Article] RIG-I Helicase-Independent Pathway in Sendai Virus-Activated Dendritic Cells Is Critical for Preventing Lung Metastasis of AT6.3 Prostate Cancer (2010)
  • Author(s): Kato T, Ueda Y, Kinoh H, Yoneyama Y, Matsunaga A, Komaru A, Harada Y, Suzuki H, Komiya A, Shibata S, Hasegawa M, Hayashi H, Ichikawa T, Yonemitsu Y
  • Journal Title: Neoplasia Volume: 12 Pages: 906-914
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978913/
  • Peer Reviewed
• [Journal Article] Carbon ion radiotherapy for treatment of prostate cancer and subsequent outcomes after biochemical failure (2010)
  • Author(s): Shimazaki J, Tsuji H, Okada T, Akakura K, Suzuki H, Harada M, Tsuji H
  • Journal Title: Anticancer Res Volume: 30 Pages: 5105-5112
  • URL: http://ar.iiarjournals.org/content/32/8/3267.full.pdf+html
  • Peer Reviewed
• [Journal Article] Hormonal therapy for prostate cancer: current topics and future perspectives (2010)
  • Author(s): Suzuki H, Hinotsu S, Akaza H, Fujii Y, Kawakami S, Kihara K, Akakura K, Suzuki M, Kitamura T, Homma Y, Mizokami A
  • Journal Title: Int J Urol Volume: 17(4) Pages: 302-313
  • DOI: DOI: 10.1111/j.1442-2042.2010.02460.x
  • Peer Reviewed
• [Presentation] 前立腺癌の新しい診療ガイドラインについて～前立腺癌に対する薬物療法のこれまでとこれから～ (2012)
  • Author(s): 鈴木啓悦
  • Organizer: 第64回日本泌尿器科学会西日本総会教育セミナー(講演)
  • Place of Presentation: 徳島県徳島市
  • Year and Date: 2012-11-09
• [Presentation] 前立腺癌の新しい診療ガイドライン～ホルモン療法の多様化と新展開～ (2012)
  • Author(s): 鈴木啓悦
  • Organizer: 第62回日本泌尿器科学会中部総会ランチョンセミナー(講演)
  • Place of Presentation: 富山県富山市
  • Year and Date: 2012-11-03
• [Presentation] ランチョンセミナー「新しい前立腺癌診療ガイドライン」特にアンドロロジーから見た薬物療法の現在と未来 (2012)
  • Author(s): 鈴木啓悦
  • Organizer: 日本アンドロロジー学会第31回学術大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2012-06-29
• [Presentation] シンポジウム「前立腺癌:ノモグラムとリスク分類の応用について」日本人データに基づいたリスク分類とノモグラム:J-CAPRA score と CHIBA nomogram (2011)
  • Author(s): 鈴木啓悦,岡了,杉浦恵子,遠藤匠,高野慎,矢野仁,直井牧人,西見大輔,神谷直人,内海孝信,川村幸治,今本敬,市川智彦
  • Organizer: 第76回日本泌尿器科学会東部総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-21
• [Presentation] シンポジウム「前立腺:発癌β増殖:ホルモンとの接点」前立腺癌と血中アンドロゲン. (2011)
  • Author(s): 今本敬、内海孝信、佐塚智和、柳澤充、矢野仁、川村幸治、神谷直人、二瓶直樹、鈴木啓悦、市川智彦
  • Organizer: 第30回日本アンドロロジー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-23
• [Presentation] 第30回記念特別企画1「前立腺癌とアンドロゲン受容体 -30 年の歴史と今後の展望-」前立腺癌におけるアンドロゲン受容体遺伝子変異. (2011)
  • Author(s): 鈴木啓悦
  • Organizer: 第30回日本アンドロロジー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-22
• [Presentation] サテライトシンポジウム「前立腺癌診療における"ノモグラム"を総括する!」前立腺癌診療ノモグラムの臨床における意義と課題. (2011)
  • Author(s): 鈴木啓悦
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-21
• [Presentation] パネルディスカッション「早期前立腺癌の治療戦略」骨盤内限局前立腺癌に対する重粒子線(炭素イオン線)治療の現状と今後の展開. (2010)
  • Author(s): 鈴木啓悦,辻比呂志, 赤倉功一郎, 市川智彦, 原田昌興, 辻井博彦, 島崎淳
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-30
• [Presentation] パネルディスカッション「骨転移の治療」未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性 (2010)
  • Author(s): 神谷直人,鈴木啓悦,遠藤匠,高野慎,矢野仁,直井牧人,西見大輔,高波眞佐治,川村幸治,今本敬,市川智彦
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-30
• [Presentation] シンポジウム「ホルモン抵抗性前立腺がん治療の現状と新たな展開」前立腺癌におけるアンドロゲン受容体を中心とした分子生物学的機序からみたホルモン依存性喪失と臨床的対策 (2010)
  • Author(s): 鈴木啓悦
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-28
• [Presentation] 再燃前立腺癌に対する薬物療法リテラシー. (2010)
  • Author(s): 鈴木啓悦
  • Organizer: 第98回日本泌尿器科学会総会(教育セミナー)
  • Place of Presentation: 岩手県盛岡市
  • Year and Date: 2010-04-29
• [Presentation] パネルデイスカッション「再燃性前立腺癌の治療戦略」再燃性前立腺癌に対するドセタキセル療法 (2010)
  • Author(s): 神谷直人,鈴木啓悦,遠藤匠,高野慎,矢野仁,川村幸治,今本敬,二瓶直樹,納谷幸男,市川智彦
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手県盛岡市
  • Year and Date: 2010-04-28
• [Book] 前立腺癌の臨床研究デザイン.坂下祥深,天願ルイス編集,成功・失敗の傾向,各疾患の特徴からつかむ臨床試験計画とデザインの設定 (2012)
  • Author(s): 神谷直人,鈴木啓悦
  • Total Pages: 242-254
  • Publisher: 株式会社 技術情報協会,東京都品川区
• [Book] 第4章泌尿器科.技術情報協会編集,治療/診断技術のニーズとシーズ評価集 (2011)
  • Author(s): 鈴木啓悦(分担)
  • Total Pages: 39-60
  • Publisher: (株)技術情報協会,東京
• [Book] アンチアンドロゲン交替療法のメカニズムと有効性について教えてください.筧善行編集,前立腺癌診療:こんなときどうする Q&A (2010)
  • Author(s): 鈴木啓悦(分担)
  • Total Pages: 185-187
  • Publisher: 中外医学社,東京
• [Book] ホルモン抵抗性前立腺癌(HRPC)の発生機序について教えてください.筧善行編集,前立腺癌診療:こんなときどうする Q&A (2010)
  • Author(s): 神谷直人,鈴木啓悦,今本敬,川村幸治,市川智彦(分担)
  • Total Pages: 196-200
  • Publisher: 中外医学社,東京
• [Remarks] ホームページ
  • URL: http://www.lab.toho-u.ac.jp/med/sakura/urology/