2012 Fiscal Year Final Research Report
Roles of irradiated stromal cells in the survival, growth , invasion of prostate carcinoma and its mechanisms
| Project/Area Number |
22591770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Saga University |
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Principal Investigator |
UOZUMI Jiro 佐賀大学, 医学部, 教授 (30223514)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Shuji 佐賀大学, 医学部, 教授 (80188755)
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| Co-Investigator(Renkei-kenkyūsha) |
TOKUDA Yuji 佐賀大学, 医学部, 講師 (90315200)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 前立腺癌 / 放射線被爆間質 / 癌間質相互作用 |
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| Research Abstract |
Adipocytes and adipose tissues, adipose tissue stromal cells (ATSC) promote the invasion of prostate cancer cell line (PC3), but the irradiated stromal cell types do not significantly affect the invasion of PC3. Irradiated ATSC tends to promote the growth of prostate cancer cell line (LNcap). To evaluate effects of irradiated stromal cells on tumor cells other than prostate tumor cells, we used bladder tumor cells in this research project. Irradiated ATSC inhibits the growth of superficial bladder cancer cell line (RT4), and promotes the apoptosis. In contrast, irradiated ATSC promotes the growth of invasive bladder cancer cell line (EJ) and inhibits the apoptosis. IrradiatedATSC promotes the expression of MAP kinase pathway in these cancer cell types.These results suggest that irradiated stromal cell types may affect tumor growth and invasion in a tumor cell type-dependent way at least in prostatic adenocarcinoma and bladder urinary carcinoma. To estimate effects of irradiated stromal cell types on prostate and bladder cancers in more detail, further studies are needed.交付決定
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