2012 Fiscal Year Final Research Report
Analysis of the regulation of androgen receptor by renin-angiotensin system in prostate cancer
| Project/Area Number |
22591774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Yokohama City University |
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Principal Investigator |
UEMURA Hiroji 横浜市立大学, 附属病院, 准教授 (50244439)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yoshinobu 横浜市立大学, 医学研究科, 教授 (10106312)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 前立腺癌 / アンドロゲンレセプター / レニン-アンジオテンシン系 |
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| Research Abstract |
We have confirmed that renin-angiotensin system have the potential to Regulate the expression of androgen receptor in prostate cancer cells via in vitro and in vivo experiment. Furthermore, we conducted a clinical study to confirm whether angiotensin II receptor blocker (ARB) would influence the development of prostate cancer .As a result, ARB has the potential to inhibit the expression of androgen receptor through AT1 receptor. Furthermore, clinical study revealed that ARB treatment delayed PSA risingin patients with PSA recurrence after prostatectomy.
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[Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer2012
Author(s)
Kobayashi N, Uemura H, Nagahama K, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
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Journal Title
Oncotarget
Volume: 3(11)
Pages: 1455-71
Peer Reviewed
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[Journal Article] The co- -6 in prostate cancer tissue correlates with biochemical recurrence2011
Author(s)
Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H.
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Journal Title
Cancer Sci
Volume: 102(8)
Pages: 1576-1581
Peer Reviewed
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