2012 Fiscal Year Final Research Report
Combined therapy for urologic cancer cells by high-intensity focused ultrasound and PEG-conjugated fullerene
| Project/Area Number |
22591783
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Aichi Medical University (2011-2012)
National Defense Medical College (2010) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ASANO Tomohiko 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40167226)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | ポリエチレングリコール / フラーレン / 癌細胞株 / 収束超音波 / 抗腫瘍効果 / 担癌マウス |
|---|
| Research Abstract |
By chemically modifying fullerene (C60) with polyethylene glycol (PEG), we succeeded in synthesizing water-soluble PEG-conjugated fullerene. MTS assays showed that thecombination of HIFU with PEG-conjugated fullerene resulted in synergistic growth inhibitory effects in PC-3 cells in vitro. In vivo, however, we failed to confirm reproducibility on the results of selective tumor tissue accumulation of fullerene because of instability of labeled PEG-conjugated fullerene. Using chicken tissue model we found synergistic tissue degenerating effects by this combination therapy, which showed no additive or synergistic antitumor effects in PC-3 xenograft models.
|
