2012 Fiscal Year Final Research Report
Survey of chronological changes of azithromycin resistance and analyses of azithromycin resistance mechanisms in clinical strains of Neisserira gonorrhoeae
| Project/Area Number |
22591788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gifu University |
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Principal Investigator |
DEGUCHI Takashi 岐阜大学, 大学院・医学系研究科, 教授 (40163935)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 感染症学 / 性感染症 |
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| Research Abstract |
Clinical strains of Neisseria gonorrhoeae isolated in 2010, 2011 and 2012 were examined for antimicrobial susceptibility to azithromycin. The MIC50 and MIC90, which were defined as minimum concentrations inhibiting the growth of 50% and 90% of the isolates, were 0.25 μg/ml and 0.5 μg/ml, 0.5 μg/ml and 1 μg/ml, and 0.25 μg/ml and 1 μg/ml for the isolates in 2010, 2011, and 2012, respectively. The 23S rRNA genes in the strains were examined for the presence of azxithromycin resistance-associated mutations. Our current study demonstrated that some clinical strains with intermediate resistance to azithromycin have emerged in Japan and that the resistance was associated with the mutation in the 23S rRNA gene.
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