2012 Fiscal Year Final Research Report
Measurements of Alanine:Glyoxylate transamination and Glyoxylate Reductase for hyperoxaluria
| Project/Area Number |
22591789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
NAGATA Masao 浜松医科大学, 医学部附属病院, 助教 (70397397)
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| Co-Investigator(Kenkyū-buntansha) |
OZONO Seiichiro 浜松医科大学, 医学部附属病院, 教授 (00183228)
TAKAYAMA Tatsuya 浜松医科大学, 医学部附属病院, 講師 (90324350)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 結石症学 |
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| Research Abstract |
The activity of SPT/AGT can be measured by SGT activity also not only in a healthy person but in PH1 patient. The activity of GR can be measured by DGDH activity, in nine stone patients' average was 1.81±0.76 nmol/min/mg protein. L-Glycerate can be measured by HPLC used a chiral column. The comparison of L-Glycerate with 52 non-stone patients (non-stone former:non-SF) and nine stone patients (stone former:SF) , The value of SF was high with non-SF 13.3micromol/L, SF 21.3micromol/L, is a significant difference at the median.
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