2013 Fiscal Year Final Research Report
Monitoring of personalized immunosuppression treatment of kidney transplant
| Project/Area Number |
22591805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tokyo Women's Medical University (2012-2013)
Nagoya University (2010-2011) |
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Principal Investigator |
MIZUTANI Kazuo 東京女子医科大学, 医学部, 助教 (20303612)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Masashi 名古屋大学, 医学部付属病院, 講師 (10362229)
SHIMIZU Tomokazu 東京女子医科大学, 医学部, 助教 (60307593)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | transplant / kidney / テーラーメード治療 / サイトカイン / HLA抗体 / MMF |
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| Research Abstract |
The aim of this study was to find the application of personalized treatment to each kidney transplant patient. In this study, besides the immunosuppression treatments and the level of calcinurin inhibitor, we found following: 1) The quantification of PHA-induced IL2 mRNA will be a useful tool for the development of personalized medicine diagnostics for measuring the efficacy of immunosuppressive drugs. 2) Kidney patients who rejected transplants had HLA antibodies more frequently than those with functioning grafts. These antibodies found in the peripheral circulation, and their association with failure is consistent in long period. 3) The Measurement of Mycophenolic acid (MPA) trough concentration was associated with kidney function and immunosuppression treatments.
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