2012 Fiscal Year Final Research Report
Development of the rational pharmacotherapy for ejaculatory disorderusing a rat evaluation model
| Project/Area Number |
22591808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
BANYA Yu 東北薬科大学, 薬学研究科, 博士課程前期
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| Project Period (FY) |
2010 – 2012
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| Keywords | アンドロロジー / 射精障害 / 動物評価モデル / 創薬 / 早漏治療薬 |
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| Research Abstract |
We previously established a rat model for the quantitative evaluation of theejaculatory function by the support of KAKENNHI (19591884). The purpose of this study is thedevelopment of the rational pharmacotherapy for ejaculatory disorder by using this model. Obtainedresults are as follows; 1) Combination of a small dose of the selective dopamine D2 receptor agonistsand the selective 5-HT2Creceptor agonists potently and selectively facilitates the ejaculatory responsethrough the activation of the central D2-like and 5-HT2Creceptors, respectively. 2) Combination ofthese receptors agonists acts synergistically to induce ejaculation without affecting micturition reflexand penile erection in rats. 3) Blockade of the central 5-HT2Creceptors obviously delays the expressionof ejaculation. These results provide useful information as to the pharmacotherapy for patients withejaculatory disorders.
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