2012 Fiscal Year Final Research Report
Molecular mechanism of aging-related decline in oocyte quality: a study of metabolomics and autophagy
| Project/Area Number |
22591815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Hideki 山形大学, 医学部, 助教 (80333970)
AMITA Mitsuyoshi 山形大学, 医学部, 助教 (30420061)
KURACHI Hirohisa 山形大学, 医学部, 教授 (40153366)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 卵の加齢 / メタボロミクス / オートファジー / 細胞内カルシウム制御機構 / ATP |
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| Research Abstract |
The age-associated decline in female fertility is largely attributableto the decrease in oocyte quality due to ovarian aging. However, the precise mechanism ofoocyte aging due to ovarian aging remains unknown. In the present study, we examined themolecular mechanisms of age-related decline in oocyte quality by metabolomics and analyzing autophagy.
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