2012 Fiscal Year Final Research Report
New therapeutic strategy of pediatric surgical treatment for repair of tissue deficits and revascularization using autologous tissue grafting
| Project/Area Number |
22591818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUBOTA Toshiro 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50126223)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Ikuo 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60100129)
OBAYASHI Satoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (10262180)
SUDO Noriko 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (30611058)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 産科学 / 再生医療 |
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| Research Abstract |
We established amnion sheets with capillary network by use of lithographic technique using outgrowth endothelial progenitor cells from umbilical cord blood and mesenchymal stem cells from Wharton’s jelly in umbilical cord. Implantation of the amnion sheet with capillary network into the ischemic hind limbs of mice increased reperfusion compared with controls. Implantation of a capillary network engineered ex vivo from autologous cells may have therapeutic potential for the treatment of pediatric surgery.
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