2012 Fiscal Year Final Research Report
Identification of the microRNA which is involved in theanti-proliferative action of estrogens
| Project/Area Number |
22591819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MITSUI Tetsuo 山梨大学, 大学院・医学工学総合研究部, 助教 (20402084)
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| Project Period (FY) |
2010 – 2012
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| Keywords | エストロジェン / 下垂体 / 細胞増殖 / microRNA / シグナル伝達 |
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| Research Abstract |
Estrogens stimulate cell proliferation of estrogen-responsiveorgans including the uterus, mammary gland, and anterior pituitary gland. Recently, wehave found that 17-β estradiol (E2) had estrogen receptor-mediated anti-mitogenic actionin presence of growth factors such as insulin-like growth factor-1 (IGF-1) on ratlactotroph primary cell culture. However, at present, the cellular and molecularmechanisms underlying the IGF-1-dependent anti-mitogenic action of estrogen uponlactotroph remain unknown. In this study, we have found the microRNA which might beinvolved in the anti-proliferative action of estrogens.
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