2012 Fiscal Year Final Research Report
Molecular mechanisms of crosstalk between fetus and mother via fetal membrane
| Project/Area Number |
22591822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KAKUI Kazuyo 京都大学, 医学研究科, 非常勤講師 (40531067)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Keiji 京都大学, 医学研究科, 非常勤講師 (10324633)
KONDO Eiji 京都大学, 医学研究科, 助教 (10544950)
KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 卵膜 / 成長因子 / 妊娠高血圧症候群 / 胎児発育遅延 / クロストーク |
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| Research Abstract |
First, we found that receptors of nerve growth factors, such as neurotrophin, were expressed in amnion, which suggested that these nerve growth factors had some roles in the signal transduction between mother and fetus. Secondaly, in primary amnion mesenchymal cells, increase of matrix metalloprotenases and cyclooxygenase type-2 by fetal fibronectin were significantly suppressed by tranexamic acid, which implied that tranexamic acid might be useful for prevention or treatment of preterm rupture of membrane and preterm birth.
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[Journal Article] Branched-chain amino acid supplemented diet during maternal food restriction prevents developmental hypertension in adult rat offspring2011
Author(s)
Fujii T, Yura S, Tatsumi K, Kondoh E, Mogami H, Fujita K, Kakui K, Aoe S, Ito H, Sagawa N, Fujii S, Konishi I
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Journal Title
Journal of Developmental Origins of Health and Disease
Volume: 2
Pages: 176-183
URL
Peer Reviewed
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[Journal Article] Thioredoxin binding protein-2 inhibits excessive fetal hypoglycemia during maternal starvation by suppressing insulin secretion in mice2010
Author(s)
Mogami H, Yura S, Tatsumi K, Fujii T, Fujita K, Kakui K, Kondoh E, Inoue T, Fujii S, Yodoi J, Konishi I
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Journal Title
Pediatr Res
Volume: 67
Pages: 138-43
DOI
Peer Reviewed
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