2013 Fiscal Year Final Research Report
Epigenetic analysis of aromatase gene toward the advanced early diagnostics in endometriosis
| Project/Area Number |
22591824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tottori University |
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Principal Investigator |
IZAWA Masao 鳥取大学, 医学部, 特任教授 (50032222)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tasuku 鳥取大学, 医学部, 教授 (40218649)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 子宮内膜症 / エストロゲン産生異常 / アロマターゼ遺伝子 / CpGアイランド / DNAメチル化 / エピゲノム異常 / 早期診断分子マーカー |
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| Research Abstract |
A marked up-regulation of aromatase gene leading to a high estrogen environment in endometriotic tissues has been suggested as the aberrant DNA methylation (Izawa et al. 2008). The observation further suggested the aberrant genome-wide DNA methylation in endometriosis. Toward the advanced early diagnostics in endometriosis, we challenged a genome-wide extraction of aberrant DNA methylation along with the epigenetic analysis of aromatase gene. We finally extracted approximately 1800 GpG sites as the candidates for early diagnostic markers in endometriosis. Case studies are under way toward the final extraction of these candidates.
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