2012 Fiscal Year Final Research Report
Genome-wide DNA methylation profile analysis relating pathogenesisof endometriosis
| Project/Area Number |
22591825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 子宮内膜症 / DNA メチル化 |
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| Research Abstract |
Genome-wide DNA methylation analysis identified numerous aberrant hypermethylated and hypomethylated CpGs present in endometrial stromal cells from chocolate cyst. Taken together with the result of transcriptome, some sets of genes are associated with pathogenesis of endometriosis. Principal component analysis indicated different DNA methylation profile in chocolate cyst cells, whereas transciptome could not. These findings imply the significance of genome wide DNA methylation analysis rather than transcriptome analysis to clarify development and characterization of endometriosis.
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