2012 Fiscal Year Final Research Report
Identification of molecular marker for placenta accreta
| Project/Area Number |
22591827
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
MASUZAKI Hideaki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00173740)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIURA Kiyonori 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (00363490)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 癒着胎盤 / 胎盤 / mRNA / microRNA / 術中超音波検査 / 母体血漿 |
|---|
| Research Abstract |
In this study, by high-throughput comparative analysis, placenta specific mRNAs/microRNAs (miRNAs) were identified. Regarding the placenta specific mRNAs, human placental lactogen (hPL) levels in maternal plasma may be a predictive marker for placenta accrete with total hysterectomy. Regarding the placenta specific microRNAs (miRNAs), most of them located on chromosome 19 microRNAs cluster region (C19MC). The expression levels of miRNAs on C19MC were increasing as the progress of pregnancy, while the expression profiling of them were not changed. The circulating levels of placenta specific miRNAs on C19MC in maternal plasma may be predictive markers for the risk of placenta accreta in cases of placenta previa. Furthermore, the intraoperative ultrasound examination is expected to be useful for evaluating the degree of placenta accrete in cases of placenta previa.
|
-
[Journal Article] Characterization ofplacenta-specific microRNAs in fetal growth restriction pregnancy2013
Author(s)
Higashijima A, Miura K, Mishima H, Kinoshita A, Jo O, Abe S, Hasegawa Y, MiuraS, Yamasaki K, Yoshida A, Yoshiura K, Masuzaki H
-
Journal Title
Prenat Diagn
Volume: 33
Pages: 214-222
-
-
-
-
-
[Journal Article] Pre-vaccinationepidemiology of human papillomavirus infections in Japanese women with abnormal cytology2011
Author(s)
Yamasaki K, Miura K, Shimada T, Ikemoto R, Miura S, Murakami M, Sameshima T,Fujishita A, Kotera K, Kinoshita A, Yoshiura K, Masuzaki H
-
Journal Title
J Obstet Gynaecol Res
Volume: 37
Pages: 1666-1670
-
-
[Journal Article] Clinicalapplication of fetal sex determination using cell-free fetal DNA in pregnant carriers of X-linked genetic disorders2011
Author(s)
Miura K, Higashijima A, Shimada T, Miura S, Yamasaki K, Abe S, Jo O, KinoshitaA, Yoshida A, Yoshimura S, Niikawa N, Yoshiura K, Masuzaki H
-
Journal Title
J Hum Genet
Volume: 56
Pages: 296-299
-
[Journal Article] Epidemiology of human papillomavirus genotypes in pregnant Japanese women2011
Author(s)
Yamasaki K, Miura K, Shimada T, Miura S, Abe S, Murakami M, Sameshima T,Fujishita A, Kotera K, Kinoshita A, Yoshiura K, Masuzaki H
-
Journal Title
J Hum Genet
Volume: 56
Pages: 313-315
-
-
-
-
-
-
-
-
[Journal Article] Copy numbervariation of the antimicrobial-gene, defensin beta 4, is associated withsusceptibility to cervical cancer
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y,Higashijima A, Jo O, Sasaki K, Yoshida A, Yoshiura KI, Masuzaki H
-
Journal Title
J Hum Genet
Volume: (in press)
-
-
-
-
-
-
-
-
