2013 Fiscal Year Final Research Report
The synthesis and function of melatonin in the ovary
| Project/Area Number |
22591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ITOH Masanori 東京医科歯科大学, 教養部, 教授 (30257349)
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| Project Period (FY) |
2010-10-20 – 2013-03-31
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| Keywords | メラトニン / セロトニン / 卵巣 / 卵母細胞 / ラット |
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| Research Abstract |
Melatonin is originally identified in the pineal gland, where it is synthesized enzymatically from serotonin by the sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT). Our data revealed that AANAT and ASMT are expressed in the adult rat ovary. like the pineal gland. AANAT protein is localized to the oocyte, corpus luteum, and medulla including mast cells. AANAT protein was found in oocytes at all stages of follicular development, and its levels in oocytes increased progressively throughout the follicular development. Furthermore, we showed that melatonin is synthesized from serotonin in oocytes. Melatonin synthesized in the oocyte may be implicated in its own growth and/or maturation, for example, by acting as a calmodulin antagonist and/or an antioxidant.
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[Journal Article] Androstenedione inducees abnormalities in morphology and function of developimg oocytes, which impairs oocyte meiotic competence2012
Author(s)
Tarumi, W., Tsukamoto, S., Okutsu, Y., Takahashi, N., Horiuchi, T., Itoh, M.T., Ishizula, B
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Journal Title
Fertil. Steril
Volume: 97
Pages: 469-476
DOI
Peer Reviewed
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[Journal Article] Number of CGG repeats in the FMR1 gene of Japanease patients with primary ovarian in insufficiency2011
Author(s)
Ishizuka, B., Okamoto, N., Hamada, N., Sugishita, Y., Saito, J., Takahashi, N., Ogata, T., Itoh, M
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Journal Title
T. Fertile. Steril
Volume: 96
Pages: 1170-1174
DOI
Peer Reviewed
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[Journal Article] Gonadotopins up-regulate the expression of enolase 2, but not, (細胞の紡錘体形成異常を誘起する)2011
Author(s)
takahashi, N., Tarumi, W., Itoh, M.T., Ishizuka, B., Yoshioka, N.
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Journal Title
Endocr. J
Volume: 58
Pages: 941-948
Peer Reviewed
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[Presentation] Androstenedione induces abnormalities in morphology and function of developing oocytes, which impairs oocyte meiotic competence2012
Author(s)
Tarumi, W., Tsukamoto, S., Okutsu, Y., Takahashi, N., Horiuchi, T., Itoh, M.T., Ishizuka, B
Organizer
The International Ovarian Conference 2012
Place of Presentation
東京
Year and Date
20120000
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[Presentation] Effects of Kava suspension prepared from roots of Piper methysticum on behaviors in mice2011
Author(s)
Murakami, S., Satou, T., Niihara, K, Itoh, M.T.,
Yoshida, M., Voro, T., Prasad, S
Organizer
International Conference on Chemistry, Environment and Climate Change 2011
Place of Presentation
フィジー共和国スヴァ
Year and Date
20110000
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[Presentation] Andorostenedione induces abnormalities in morphology and function of developing oocytes, which impairs oocyte meiotic competence2011
Author(s)
Tarumi, W., Tsukamoto, S., Okutsu, Y., Takahashi, N., Horiuchi, T., Itoh, M.T., Ishizuka, B.
Organizer
16 th World Congress on In Vitro Fertilization/5^<th> World Congress on In Vitro Maturation
Place of Presentation
仙台
Year and Date
20110000
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[Book]2011
Author(s)
石塚文平, (鈴木秋悦編)
Total Pages
2-8
Publisher
医歯薬出版
