2012 Fiscal Year Final Research Report
Investigation for the molecular mechanism of the association between obesity and endometrial cancer
| Project/Area Number |
22591849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
QUAN Jinhua 新潟大学, 医歯学系, 助教 (10452070)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 子宮体癌 / Leptin / 肥満 |
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| Research Abstract |
We demonstrated the presence of elevated leptin and leptin/adiponectin (L/A) ratios in Japanese postmenopausal endometrial cancer patients. The leptin and L/A ratios were associated with an increased risk of endometrial cancer development after the normalization of the BMI, suggesting that the leptin and L/A ratio is a predictor of endometrial cancer risk, independent of obesity. Elevated Cyclin D1 expression was observed after leptin treatment for endometrial cancer cells and JAK/STAT pathway was mainly associated for the expression of CyclinD1. Estrogen and leptin stimulated endometrial cancer cell proliferation in a coordinated manner.
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