2012 Fiscal Year Final Research Report
The comprehensive study on diagnosis and treatment of minimal deviation adenocarcinoma and related disease of the cervix
| Project/Area Number |
22591851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKATSU Akiko 信州大学, 医学部附属病院, 助教 (90447730)
SHIOZAWA Tanri 信州大学, 医学部, 教授 (20235493)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 悪性腺腫 / 分葉状頸管腺過形成 / 術前診断 / MRI / 細胞診 / クローン性 |
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| Research Abstract |
Present study of 112 cases demonstrated that over 90% cases of adenocarcinoma including minimal deviation adenocarcinoma (MDA) could be distinguished from benign lesion of the cervix such as lobular endocervical glandular hyperplasia (LEGH) by magnetic resonance imaging (MRI), Papanicolaou cytology and cone biopsy. The clonality analysis revealed that 4 of 6 LEGH lesions associated with MDA or adenocarcinoma were monoclonal, and the patterns of X chromosome inactivation in monoclonal LEGH lesions were identical to those in coexisting malignant lesions. The mutation of STK11 was only identified in one MDA, but not in LEGH. These results indicated that a subset of LEGH may be a precursor to malignant tumors including MDA.
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[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.2011
Author(s)
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
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Journal Title
Int J Gynecol Cancer
Volume: 21
Pages: 1287-86
Peer Reviewed
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