2012 Fiscal Year Final Research Report
The molecularendocrinological strategy using pregnaneX receptor in drug-resistant ovarian cancer
| Project/Area Number |
22591856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Okayama University |
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Principal Investigator |
MASUYAMA Hisashi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (30314678)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAMATSU Yuji 岡山大学, 大学院・医歯薬学総合研究科, 教 授 (80218817)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 卵巣癌 / 薬物耐性 / 核内受容体 |
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| Research Abstract |
Recent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of drug-metabolizing enzymes, CYP3A family, as well as members of the drug transporter family, including MDR1. We observed that PXR-MDR pathway was expressed in various ovarian cancer tissues and that PXR down-regulation caused a significant increase in cell growth inhibition and enhancement of apoptosis in the presence of the anti-cancer agents, paclitaxel, cisplatin. PXR down-regulation could be a novel therapeutic approach for the augmentation of sensitivity to anticancer agents, or to overcome resistance to them, in the treatment of ovarian cancer.
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