2012 Fiscal Year Final Research Report
The mechanism of acquisition of metastatic and invasive capacityin endometrial cancer cell
| Project/Area Number |
22591868
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Kiyoko 順天堂大学, 医学部, 准教授 (10253527)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 子宮体癌 / 癌幹細胞 / EMT / 転移能 / SPARC |
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| Research Abstract |
We select SPARC (secreted protein acidic and rich in cystein) from the gene clusters which revelation is increasing to the endometrial cancer stem cell, and analyzed it. There is no-expression of SPARC in normal endometrium, but highly expressed in the endometrial cancer, especially in poorly differentiated adenocarcinoma of uterine corpus. These data showed that SPARC was associated with micro-environment of tumor-stroma formation and the migration capability.
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