2012 Fiscal Year Final Research Report
A novel method for analyzing inner ear disorders using disease-specific iPS cells
| Project/Area Number |
22591878
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAJIRI Shin-ichiro 京都大学, 医学研究科, 助教 (00532970)
SAKAMOTO Tatsunori 京都大学, 医学研究科, 助教 (60425626)
YAMAMOTO Norio 京都大学, 医学研究科, 助教 (70378644)
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| Project Period (FY) |
2010 – 2012
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| Keywords | iPS細胞 / 遺伝性難聴 / 内耳再生 / 感音難聴 / 幹細胞 |
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| Research Abstract |
To utilize disease-specific iPS cells for the development of novel therapeutics for inner ear diseases, methods for otic induction of iPS cell have been developed, which have high efficiency for induction of hair cell-like cells. We also generated iPS cell lines derived from TRIOBP deficiency mice, and examined their potential for hair cell differentiation. For further progress, a method for induction of mature hair bundles should be established.
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