2012 Fiscal Year Final Research Report
The Change of Heat Shock Response in the Aging Inner Ear
| Project/Area Number |
22591882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内耳 / 老化 / 熱ショック応答 |
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| Research Abstract |
In an aging society, age-related hearing loss is one of the factors to reduce the QOL of the elderly. In the study, we examined gene expression in inner ear of age-related deafness mouse model, as the senescence-associated genes are involved in the development of presbycusis. I was no change in the gene associated with aging in the study using (HSF1-deficient mice, TSOD mouse) mice exhibit symptoms similar to presbycusis. However, the expression of IGF-1 gene decreased in aging TSOD mouse. The expression of the other kinds of gene was changed. We are analyzing the reason for the change of the gene expression after aging.
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