Comprehensive analysis of the thyroid undifferentiated conversion by using a mass spectrometry

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University
• Principal Investigator: KITAMURA Morimasa 京都大学, 医学研究科, 助教 (60543262)
• Co-Investigator(Kenkyū-buntansha): HIRANO Shigeru 京都大学, 大学院・医学研究科, 講師 (10303827) ; TATEYA Ichirou 京都大学, 大学院・医学研究科, 助教 (20526363) ; KADA Shinpei 京都大学, 大学院・医学研究科, 医員 (70543263)
• Co-Investigator(Renkei-kenkyūsha): SETOU Mitsutoshi 浜松医科大学, 解剖学講座 細胞生物学分野, 教授 (20302664)
• Project Period (FY): 2010 – 2012
• Keywords: 質量顕微鏡 / 甲状腺癌 / 未分化転化

Research Abstract

It was revealed that one type of Sphingomyelin and two types of phosphatidylcholine in thyroid papillary carcinoma are more expressed as compared with normal thyroid tissue by using a mass spectrometry. Sphingomyelin or phosphatidylcholine is a type of phospholipid, and it is classified by each lipid acid constituting each phospholipid.But it is not known whether there is a biological meaningor a characteristic of the cancer due to the differences in fatty acid.Ten types of lipid were expressed in undifferentiated carcinoma more than in normal thyroid tissue. It is generally known that undifferentiated carcinoma has much gene mutation as compared with papillary carcinoma. Therefore each difference in lipid distribution was expected to be large in undifferentiated carcinoma. But in fact the difference in undifferentiated carcinoma was smaller than that in papillarycarcinoma.

Research Products

• [Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer (2012)
  • Author(s): Ishikawa S, Tateya I, Hayasaka T, Masaki N, Takizawa Y, Ohno S, Kojima T, Kitani Y, Kitamura M, Hirano S, Setou M, Ito J
  • Journal Title: PLos One Volume: 7(11) Pages: e48873
  • DOI: doi:10.1371/journal.pone.0048873
• [Journal Article] 頭頸部扁平上皮癌の分子生物学 (2012)
  • Author(s): 石川征司、楯谷一郎、平野 滋、伊藤壽一
  • Journal Title: 耳鼻咽喉科臨床 Volume: 105巻 4号 Pages: 393-402
• [Presentation] 質量顕微鏡による甲状腺癌の観察 (2011)
  • Author(s): 石川征司、楯谷一郎、早坂孝宏、瀧澤義徳、大野 覚、児嶋 剛、木谷芳晴、北村守正、平野 滋、瀬藤光利、伊藤壽一
  • Organizer: 第112回日本耳鼻咽喉科学会
  • Place of Presentation: 京都
  • Year and Date: 20110519-21
• [Presentation] Biomarker profiling of thyroid cancer by imaging mass spectrometry (2011)
  • Author(s): Seiji Ishikawa, Ichiro Tateya, Takahiro Hayasaka, Yoshinori Takizawa, Satoshi Ohno, Tsuyoshi Kojima, Yoshiharu Kitani, Morimasa Kitamura, Shigeru Hirano, Mitsutoshi Setou, Juichi Ito
  • Organizer: Combined Otolaryngology Spring Meetings.
  • Place of Presentation: Chicago
  • Year and Date: 20110427-0501
• [Presentation] 質量顕微鏡法による甲状腺癌の観察 (2010)
  • Author(s): 石川征司、楯谷一郎、平野 滋、北村守正、嘉田真平、伊藤壽一
  • Organizer: 第43回日本甲状腺外科学会
  • Place of Presentation: 倉敷
  • Year and Date: 20101014-15