Elucidation of the molecular mechanism of the tonsillitis by new inhibitory receptor Siglec-2 and -6

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University
• Principal Investigator: YOKOI Naoko 順天堂大学, 医学部, 准教授 (60306975)
• Co-Investigator(Kenkyū-buntansha): YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
• Project Period (FY): 2010 – 2012
• Keywords: 扁桃 / Siglec-2 / Siglec-6

Research Abstract

Siglec-2 is expressed in large amounts in B-cell areas of the lymphoid follicles in the tonsils, and its expression is particularly strong in the mantle zone, which is the area of accumulation of relatively small lymphocytes similar to those found in the epithelial side. Further, Siglec-6 has been shown to be expressed in the mast cells in the connective tissue and T -cell areas, namely, in the interfollicular region; however, the expression levels differed depending on the sample. The expression levels of Siglec-2 and Siglec-6 in mast cells and B cells in focal tonsillitis, chronic tonsillitis, and tonsillar hypertrophy were analyzed and compared, but no apparent significant difference was found.

Research Products

• [Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma (2012)
  • Author(s): Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y.
  • Journal Title: Cancer Biomark Volume: 12(3) Pages: 141-8
• [Journal Article] Novel use of a Weerda laryngoscope for transoral excision of a cervical ganglioneuroma: a case report (2012)
  • Author(s): Yokoi H, Arakawa A, Inoshita A, Ikeda K
  • Journal Title: Journal of Medical Case Reports 2012 Volume: 6 Pages: 88
• [Journal Article] Heme oxygenase-1 expression in chronic rhinosinusitis with eosinophilic infiltration (2012)
  • Author(s): Kawano K, Kusunoki T, Ono N, Yao T, Saito T, Yokoi H, Ikeda K
  • Journal Title: Auris Nasus Larynx Volume: 39(4) Pages: 387-92
• [Journal Article] Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients (2012)
  • Author(s): Sato D, Suzuki Y, Kano T, Suzuki H, Matsuoka J, Yokoi H, Horikoshi S, Ikeda K, Tomino Y.
  • Journal Title: Nephrol Dial Transplant Volume: 27(3) Pages: 1090-7
• [Journal Article] An immunohistochemical study of sinonasal hemangiopericytoma (2011)
  • Author(s): Yokoi H, Arakawa A, Kuribayashi K, Inoshita A, Haruyama T, Ikeda K.
  • Journal Title: Auris Nasus Larynx. Volume: 38 Pages: 743-6
• [Journal Article] An inflammatory calcified nodule in the buccal subcutis-A case report (2011)
  • Author(s): Yokoi H, Yoshikawa H, Matsumoto T, Kawano K, Ikeda K
  • Journal Title: B-ENT. Volume: 7(3) Pages: 215-8
• [Journal Article] Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma (2011)
  • Author(s): Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 469-73
• [Journal Article] Relationship between olfactory acuity and peak expiratory flow during postoperative follow-up in chronic rhinosinusitis associated with asthma. (2010)
  • Author(s): Ikeda K, Yokoi H, Kusunoki T, Saito T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K
  • Journal Title: Ann Oto Rhinol Laryngol Volume: 119 Pages: 749-754
• [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells (2010)
  • Author(s): Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
  • Journal Title: J Immunol Volume: 184 Pages: 3526-34
• [Journal Article] Organized hematoma of the maxillary sinus: A clinicopathologic study of five cases
  • Author(s): Yokoi H, Arakawa A, Saito T, Matsumoto F, Matsumoto, Haruyama T, Yokoi N, Ikeda K
  • Journal Title: Journal of ENT Volume: (in press)