2012 Fiscal Year Final Research Report
Development of a novel approach to translymphatic chemotherapy targeting sentinel lymph nodes of patients with head and neck cancer
| Project/Area Number |
22591920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Yasuhisa 愛知県立がんセンター, 研究員 (10261207)
IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
ITO Shin 順天堂大学, 医学部, 准教授 (80365577)
OHBA Shinichi 順天堂大学, 医学部, 助教 (20549274)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リンパ管化学療法 / センチネルリンパ節 / 低侵襲治療 / ドラッグデリバリーシステム / targeting Chemotherapy / 頭頸部癌 / Lyposome |
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| Research Abstract |
Introduction Neck metastasis is a significant prognostic factor of tongue cancer. Our goal is to establish lymphatic chemotherapy targeting neck metastases in patients with tongue cancer (cT3N2bM0) using intra-arterial chemotherapy. Methods Patients with tongue cancer (cT3N2bM0) were treated by intra-arterial chemotherapy as neoadjuvant chemotherapy. After a week of chemotherapy, patients underwent surgical treatment. CDDP was administered through Intra-arterial chemotherapy. At the beginning of surgery, 5 mg of indocyanine green (ICG) was administered to the feeding artery. Metastatic lymphnodes were detected using ICG fluorescence imaging and a conventionalradioactive method of intra-tumor injection a day before surgery. Results The mean CDDP concentrations in the metastasis and non-SLNs were 2.35 μg/g and 1.08 μg/g, respectively (p = 0.034). Of 27 metastatic nodes, 24 (89%) were identified by ICG fluorescence imaging; however, only 18 (67%) were identified by the conventional local injection method because of occlusion of afferent lymphatics from the tongue cancer. (p = 0.043). Of 22 measurable metastatic nodes, 14 responded (partial response) and 8 did not respond (stable disease). Apoptosis was detected in all metastatic nodes.Conclusion CDDP concentrations in metastatic nodes were significantly higher than those in non -SLNs. This novel drug-delivery system is feasible for lymphatic chemotherapy targeting metastatic nodes in patients with tongue cancer.
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