2012 Fiscal Year Final Research Report
Investigation of prostaglandins receptors and their clinicalsignificance in head and neck squamous cell carcinoma
| Project/Area Number |
22591923
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KAWATA Ryo 大阪医科大学, 医学部, 教授 (40224787)
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| Co-Investigator(Kenkyū-buntansha) |
LEE Kotetsu 大阪医科大学, 医学部, 講師 (10368087)
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| Project Period (FY) |
2010 – 2012
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| Keywords | プロスタグランジン / シクロキシゲナーゼ / 頭頸部扁平上皮癌 / PGE 合成酵素PGE 受容体 / 転移 |
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| Research Abstract |
Overexpression of both cyclooxygenase (COX) -2 and mPGES-1 were evaluated by immunohistochemistry in head and neck squamous cell carcinoma. Localization of COX-2 and mPGES-1 was very similar, and well-differentiated tumors showed stronger expression than poorly differentiated tumors. The COX-2 and mPGES-1 mRNA were significantly higher in well-differentiated carcinomas and N0 patients.Receptors of PGE2, EP1 to EP4 were all expressed in carcinoma cells, especially in EP2.
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