2012 Fiscal Year Final Research Report
Identification for glaucoma related genes and application for diagnosis and pharmacogenomics
| Project/Area Number |
22591928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUSE Nobuo 東北大学, 東北メディカル・メガバンク機構, 教授 (10302134)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 遺伝学 / 遺伝子 / ゲノム / 臨床 |
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| Research Abstract |
We have done the screening for the glaucoma genes using the single nucleotide polymorphisms (SNPs). Using association study, we identified the glaucoma susceptibility genes for primary open angle glaucoma, normal tension glaucoma, and exfoliation glaucoma. We also detect the rare amino acid substitutions in glutamate transporter gene GLAST by candidate gene approach. By the association study using SNPs and candidate gene approach, we detected glaucoma susceptibility genes.
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[Journal Article] Association of HK2and NCK2 with Normal Tension Glaucoma in the Japanese Population2013
Author(s)
Shi D, Funayama T, Mashima Y, Takano Y,Shimizu A, YamamotoK, Mengkegale M, Miyazawa A, Yasuda N, Fukuchi T, Abe H, Ideta H, Nishida K, Nakazawa T, Richards JE, Fuse N.
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Journal Title
PLoS ONE
Volume: 8; e54115
Pages: 1-11
Peer Reviewed
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[Journal Article] Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open angle, normal tension, and exfoliation glaucoma2012
Author(s)
Takano Y, Shi D, Shimizu A, Funayama T, Mashima Y, Yasuda N, Fukuchi T, Abe H, Ideta H, Zheng X, Shiraishi A, Ohashi Y, Nishida K, Nakazawa T, Fuse N.
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Journal Title
Am J Ophthalmol
Volume: 154
Pages: 825-832
DOI
Peer Reviewed
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