2012 Fiscal Year Final Research Report
Elucidation of the role of ER stress in neuronal abnormalities of diabetic retinopathy
| Project/Area Number |
22591931
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 眼細胞生物学 |
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| Research Abstract |
We have demonstrated that mitochondria-caspase dependent cell death pathways are associated with neuronal cell death in cultured rat retinas under diabetic stress. In addition, we have suggested that ER stress-related cell death pathways are related to neuronal cell death in cultured diabetic rat retinas and in human diabetic retinas. Taken together, our results indicate that there are a molecular crosstalk between mitochondria and ER stress cell death pathways in diabetic retinas. Furthermore, BDNF, NT-4 and citicoline rescued neuronal cell death and induce neurite regeneration in cultured diabetic rat retinas. Especially NT-4 showed the most neuroprotective and regenerative effect in damaged retinal neurons of diabetic retinas.
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