2012 Fiscal Year Final Research Report
Development of novel endothelial keratoplasty (nDSAEK) for bullous keratopathy and its visual function analysis
| Project/Area Number |
22591934
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 角膜移植 / 角膜内皮移植 |
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| Research Abstract |
According to a research project, we conducted a research to compare the clinical results after DSAEK(Descemet stripping automated endothelial keratoplasty)and nDSAEK(non-Descemet stripping automated endothelial keratoplasty). As a result, no statistical difference was observed between these two groups in terms of the visual acuity, and best corrected visual acuity, endothelial cell density. Also, no differencewas observed for donor adherence rate. In vivo laser confocal microscopy revealed that subepithelial opacity, stromal needle shaped bodies, donor recipient interface opacity and particles. Most notably, giant hyperreflective materials were observed at donor recipient interface only in nDSAEK group; these were considered to be necrotic and aggregated host endothelial cells and seemed to have no side effect to postoperative visual acuity.
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Research Products
(34 results)
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[Journal Article] Mathematical projection model of corneal endothelial cell loss due to Fuchs corneal dystrophy2011
Author(s)
Hatou S, Shimmura S, Shimazaki J, Usui T, Amano S, Yokogawa H, Kobayashi A, Shiraishi A, Ohashi Y, Inatomi T, Kinoshita S, Tsubota K
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 7888-7893
DOI
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