2012 Fiscal Year Final Research Report
Role of sympathetic nervous system in diurnal fluctuation of intraocular pressure
| Project/Area Number |
22591935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIYAMA Kazuhisa 金沢大学, 医学系, 教授 (80179168)
HIGASHIDE Tomomi 金沢大学, 大学病院, 講師 (20291370)
TAKEDA Hisashi 金沢大学, 大学病院, 助教 (40436811)
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| Research Collaborator |
GAO Yanlin 金沢大学, 医学系研究科, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | 眼圧 / 日内変動 / アドレナリン受容体 |
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| Research Abstract |
Intraocular pressure (IOP) is the most important identified risk factor of glaucoma and diurnal IOP fluctuations are another risk factor that can influence development of glaucoma. We analyzed the relationship between genetic polymorphisms of the adrenergic receptor (ADR) and diurnal IOP in untreated normal tension glaucomapatients. For Del 301-303 in α2B-ADR, Del 322-325 in α2C-ADR, and S49G (A/G) in β1-ADR, results of repeated measures analysis of variance showed that the major allele homozygote and minor allele carrier had parallel diurnal IOP curves but significantly different diurnal IOP levels.
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