2012 Fiscal Year Final Research Report
Identification of candidate genes responsible for an increased susceptibility of age-related macular degeneration using an animal model and its application to gene diagnosis.
| Project/Area Number |
22591939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OHISHI Kentaro 浜松医科大学, メディカルフォトニクス研究センター, 助教 (80345826)
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| Co-Investigator(Kenkyū-buntansha) |
HOSONO Katsuhiro 浜松医科大学, 医学部, 助教 (60402260)
OBANA Akira 浜松医科大学, メディカルフォトニクス研究センター, 客員教授 (40194625)
HOTTA Yoshihiro 浜松医科大学, 医学部, 教授 (90173608)
MINOSHIMA Shinsei 浜松医科大学, メディカルフォトニクス研究センター, 教授 (90181966)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 網膜光障害 / 連続戻し交配 / モリス水迷路 / 多型解析 / 加齢黄斑変性 |
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| Research Abstract |
To elucidate the mechanism underlying the molecular pathogenesis of age-related macular degeneration (AMD), we employed a rat experimental model of retinal photic injury induced by bright, white light exposure. Since the injury susceptibility depends on the rat strain, we started to identify a gene responsible for the susceptibility . In this study, we narrowed down the gene-containing region to 0.99 Mb on rat chromosome 5. It is thought that the 0.99 Mb region contains a key gene which also affects the pathogenesis of AMD. In future, we will identify the responsible gene, and eventually to harness it for an etiology of AMD.
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[Presentation] Genetic Analysis of Rat Strain-dependent Difference in the Susceptibility to Retinal Photic Injury and Mapping Possible Susceptibility Loci2011
Author(s)
Ohishi, K., Hosono, K., Obana, A., Hotta, Y., Hiramitsu, T., Minoshima, T
Organizer
4th International Conference on Health and Longevity Sciences (ICHALS)
Place of Presentation
Shizuoka
Year and Date
2011-10-21
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