2012 Fiscal Year Final Research Report
Study on molecular mechanism causing cancer-associated retinopathy by aberrant expression of photoreceptor specific recoverin
| Project/Area Number |
22591945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Futoshi 札幌医科大学, 医学部, 講師 (00419962)
MAEDA Kimihito 札幌医科大学, 医学部, 助教 (00452970)
OHGURO Ikuyo 札幌医科大学, 医学部, 研究員 (90305235)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌関連網膜症 / リカバリン / 異所性発現 |
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| Research Abstract |
T o elucidate the molecular pathology in CAR, expressions of recoverin were examined. Recoverin was identified to be expressed in 30-70% of cancer tissues. We observed co-precipitation of G-protein-coupled-kinases (GRKs) and caveolin-1 with Rec from cell lysates of 293 or SSTW cells. Immunocytechemistry revealed that immunoreactivitiestoward recoverin within the cancer cells were almost identical to those toward GRKs and caveolin-1. The present data strongly suggests that aberrantly expressed recoverin should be involved in the GRK-dependent cellular regulation in cancer cells.
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Research Products
(36 results)
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[Journal Article] Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011
Author(s)
Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T
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Journal Title
PLOS ONE
Volume: 6(5)
Pages: 1-7
Peer Reviewed
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