2012 Fiscal Year Final Research Report
Structural and Functional Evaluation of Blood-Ocular-Barrier
| Project/Area Number |
22591953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
ZAKO Masahiro 愛知医科大学, 医学部, 教授 (80298596)
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| Co-Investigator(Kenkyū-buntansha) |
YONEDA Masahiko 愛知県立看護大学, 看護学部, 教授 (80201086)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血液房水関門 / ぶどう膜炎 / 腫瘍壊死因子 / 抗腫瘍壊死因子抗体 / マトリックスメタ ロプロテアーゼ(MMP) |
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| Research Abstract |
Induction of matrix metalloproteinases (MMPs) in non-pigmented ciliary epithelium (HNPCECs) by tumor necrosis factor-alpha (TNF-α) was counteracted by infliximab. Immunostaining showed that the MMPs degraded claudin-1 and occludin, major components of the tight junctions in the blood-aqueous barrier, in HNPCECs and in non-pigmented ciliary epithelial cells of the swine ciliary body.
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