2012 Fiscal Year Final Research Report
Involvement of autophagy in MNU-induced retinal degeneration model and its molecular control
| Project/Area Number |
22591954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUBURA Airo 関西医科大学, 医学部, 教授 (90098137)
YURI Takashi 関西医科大学, 医学部, 講師 (50330212)
UEHARA Norihisa 関西医科大学, 医学部, 講師 (30368211)
KIMURA Ayako 関西医科大学, 医学部, 助教 (80548397)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アポトーシス / オートファジー / カルパイン阻害剤 / 眼病理学 / 視細胞 / 実験動物学 / 毒性 / 網膜色素変性症 |
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| Research Abstract |
Autophagy (AP) is intracellular protein degradation pathway that eukaryote universally possesses, and AP contributes to neuronal degenerative diseases and eye diseases such as age-related macular degeneration and glaucoma. In our research, MNU-induced and genetic retinal degeneration mouse models were related to the inhibition of AP in retina. Calpain inhibitor successfully ameliorated photoreceptor cell death in MNU-induced mouse model, which restored basal level of AP in retina.
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Research Products
(14 results)
