2012 Fiscal Year Final Research Report
Comprehensive study of superior oblique muscle palsy
| Project/Area Number |
22591964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Okayama University |
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Principal Investigator |
OHTSUKI Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70093672)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Manabu 岡山大学, 岡山大学病院, 助教 (00548505)
KONO Reika 岡山大学, 医学部, 客員研究員 (40301296)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 上斜筋麻痺 / 遺伝子多型 / 表現型 / 高解像度MRI / 眼窩プリー / Listing平面 / 眼球反対回旋 |
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| Research Abstract |
Patients with ARIX and/or PHOX2B polymorphisms had significantly greater paretic-side/normal-side ratios of the muscle compared with patients without the polymorphisms. Superior oblique muscle atrophy could be defined quantitatively as a ratio of 0.75 or less. Approximately 50% of patients exhibited superior oblique atrophy in the MRI images. The effect of oblique muscle surgery on rectus muscle pulleys was the amount ocular torsion, not the difference in surgical procedure induced by oblique muscle surgery. The wide range of difference in orientation of Listing plane can be measured with a Synoptometer, and can differentiate superior oblique muscle palsy into 2 types. Hyperdeviation between ipsilesional head tilt and the upright position can be explained by decreased compensatory ocular counterrolling due to the decreased torque of the paretic superior oblique muscle.
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Research Products
(30 results)
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[Presentation]2012
Author(s)
宮田 学,中原龍一, 長谷部 聡, 古瀬 尚, 濱崎一郎,大月 洋
Organizer
第116回日本眼科学会総会
Place of Presentation
東京
Year and Date
2012-04-06
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