2012 Fiscal Year Final Research Report
Study on the mechanisms that regulate the proliferation of Muller glia
| Project/Area Number |
22591968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Women's Medical University (2011-2012)
Toho University (2010) |
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Principal Investigator |
FUJIEDA Hiroki 東京女子医科大学, 医学部, 教授 (70280972)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 網膜 / 変性 / 細胞周期 / DNA 損傷 / p53 / ミュラー細胞 |
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| Research Abstract |
We analyzed the proliferative capacity of Muller glia in rodent models of photoreceptor damage. No proliferation was observed in the mouse retina whereas almost all Muller glia reentered the cell cycle in the rat retina; however, rat Mullerglia underwent the DNA damage response and p53 activation, leading to cell death. Thus, the DNA damage response in Muller glia may be one of the mechanisms underlying the limitedregenerative capacity of the mammalian retina
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