2012 Fiscal Year Final Research Report
Determination of neuro-protective effects of statin on the retinal injuries through activated glial cells.
| Project/Area Number |
22591973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
OKU Hidehiro 大阪医科大学, 医学部, 准教授 (90177163)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
FUKUHARA Masayuki 大阪医科大学, 医学部, 非常勤講師 (00238510)
OKUNO Takashi 大阪医科大学, 医学部, 非常勤講師 (20411366)
ISHIZAKI Eisuke 大阪医科大学, 医学部, 助教 (70530434)
KOBAYASHI Takatoshi 大阪医科大学, 医学部, 助教 (10567093)
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| Co-Investigator(Renkei-kenkyūsha) |
HARA Hideaki 岐阜薬科大学, 薬学部, 教授 (20381717)
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| Research Collaborator |
SUGIYAMA Tetsuya 大阪医科大学, 医学部, 講師 (20298764)
HORIE Taeko 大阪医科大学, 医学部, 研究助手
TONARI Masahiro 大阪医科大学, 医学部, 大学院生
MORISHITA Seita 大阪医科大学, 医学部, 大学院生
KURIMOTO Takuji 大阪医科大学, 医学部, 助教 (50388815)
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| Project Period (FY) |
2010 – 2012
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| Keywords | スタチン / アストロサイト / CD68 / 視神経挫滅モデル / 網膜神経節細胞 / NFκ B |
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| Research Abstract |
We determined neuroprotective properties of systemic statin using optic nerve crush model of rats. There was an accumulation of CD68-positive cells at the crushed site, and the immunoreactivity to MCP-1 was intensified around the lesion. There was an increase in the mRNA levels of the CD68, MCP-1, TNF-α, etc. Systemic statin significantly depressed these inflammatory changes, and rescued the retinal ganglion cells (RGCs) after the injury. Statin significantly reduced the NF-κB activation in cultured astrocytes. Thus, simvastatin may have protective roles on the RGCs possibly through suppression of astroglial NF-κB activation.
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[Journal Article]2012
Author(s)
Shibata M, Sugiyama T, Kurimoto T, Oku H, Okuno T, Kobayashi T, Ikeda T.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 53
Pages: 3726-32
DOI
Peer Reviewed
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[Journal Article]2011
Author(s)
Shibata M, Sugiyama T, Hoshiga M, Hotchi J, Okuno T, Oku H, Hanafusa T, Ikeda T
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Journal Title
Exp Eye Res.
Volume: 93
Pages: 818-24
DOI
Peer Reviewed
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[Journal Article]2011
Author(s)
Sugiyama T, Shibata M, Kajiura S, Okuno T, Tonari M, Oku H, Ikeda T.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 52
Pages: 64-9
DOI
Peer Reviewed
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