2012 Fiscal Year Final Research Report
Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
| Project/Area Number |
22591976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Chiba University |
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Principal Investigator |
YOSHIDA Hideo 千葉大学, 大学院・医学研究院, 教授 (60210712)
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| Co-Investigator(Kenkyū-buntansha) |
HISHIKI Tomoro 千葉大学, 大学院・医学研究院, 講師 (00375776)
KAMIJO Takehiko 千葉県がんセンター(研究所), 発がん研究グループ, 部長 (90262708)
SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Takeshi 千葉大学, 大学院・医学研究院, 講師 (20406044)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経芽腫 / 腫瘍融解ウイルス / がん幹細胞 |
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| Research Abstract |
Cancer stem cells have potentials of self-renewal and differentiate. Cancer stem cell-like cells could be extracted through the sphere culture method. Neuroblastoma cell line IMR32 and sIMR32 (cells extracted through sphere culture) were compared for chemosensitivity. IMR32 were more susceptible to cisplatin treatment. However, there was no difference in the cytotoxicity by HSV-1.
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[Journal Article] Reevaluation of trkA expression as a biological marker of neuroblastoma by high-sensitivity expression analysis--a study of 106 primary neuroblastomas treated in a single institute2012
Author(s)
Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H.
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Journal Title
J Pediatr Surg
Volume: 45
Pages: 2293-2298
Peer Reviewed
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[Journal Article] Src kinase family inhibitor PP2 induces aggregation and detachment of neuroblastoma cells and inhibits cell growth in a PI3 kinase/Akt pathway-independent manner2011
Author(s)
Hishiki T, Saito T, Sato Y, Mitsunaga T, Terui E, Matsuura G, Saito E, Shibata R, Mise N, Yokoyama Y, Yoshida H.
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Journal Title
Pediatr Surg Int
Volume: 27
Pages: 225-230
Peer Reviewed
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[Journal Article] Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma2010
Author(s)
Ochiai H, Takenobu H, Nakagawa A,Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T.
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Journal Title
Oncogene
Volume: 29
Pages: 2681-2690
Peer Reviewed
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